Integrative Cancer Care
/ Tammy GrimeWhat is Cancer?
Simply put, cancer is the uncontrolled growth of abnormal, non-functional cells. Cancer cells are abnormal in that they are cells that haven’t fully matured or differentiated into fully developed, working cells of the type of tissue they originate from. Cancer cells have broken genetic mechanisms that control growth and cellular reproduction allowing them to divide and replicate in an uncontrolled fashion. Normal cells have a self-destruct mechanism (called apoptosis) if they become abnormal or damaged. Cancer cells have turned off this mechanism. They are non-functional, resource-consuming cells that can impede the function of organs and may eventually consume too many of the resources that your body requires to live. These cells are progeny of your own cells and thus contain the same DNA and intelligence of your own cells. They know how to direct your body to grow a blood supply to support it’s growth. They know how to redirect your immune system to avoid detection. “Cancering” is a process involving the whole system; the interplay between the cellular environment, cellular gene regulation, mitochondria function, the immune system, lymphatic system and involves all systems of elimination.
How does cancer develop?
This is a complex question with many variables. Simply put, cancer happens due to damage to the genetic material inside a cell. Specifically, damage has occurred to
c) Genes that regulate abnormal cell death
a) Genes that control DNA repair
b) Genes that control rate of cell division
c) Genes that regulate abnormal cell death
According to the Mayo clinic, risk factors for sustaining genetic damage are: smoking, radiation, viruses, cancer-causing chemicals (carcinogens), obesity, hormones, chronic inflammation and a lack of exercise. Let's look at this a little more deeply:
d) New evidence suggest that in many cancers damage to the mitochondria in cells(the cell organelle that produces energy), creates a toxic intracellular environment that causes DNA damage.
How does this damage happen?
According to the Mayo clinic, risk factors for sustaining genetic damage are: smoking, radiation, viruses, cancer-causing chemicals (carcinogens), obesity, hormones, chronic inflammation and a lack of exercise. Let's look at this a little more deeply:
1. Free radical damage/oxidative damage.
Free radical damage comes from radiation (eg. Solar radiation and skin cancer, electromagnetic radiation, x-rays etc.), pollution, chemical toxicity (pesticides, PCBs, dioxins, cigarette smoke, flame retardants, chemicals in hair-dyes, cleaning agents, Teflon etc, etc.). Lacking a sufficient supply of antioxidants from your diet to protect yourself from your exposures, lacking proper function of the biochemistry required to produce or recycle antioxidants, or lacking the nutrients or chemistry to neutralize toxins. Genetic material that codes for the cellular processes that control cell division become damaged and the result is uncontrolled cell growth.
2. Viruses and bacteria.
We know that many cancers are the result of infections. Viruses are odd entities that function by inserting their DNA into the DNA contained in your own cells and temporarily “hijacking” your cells. Eg. Certain strains of the Human Papilloma Virus (HPV) cause cervical cancer. Hep C often eventually causes liver cancer. Like HPV, many viruses don’t cause acute infection-type symptoms, but can “hang out” in our body and assimilate – either causing harm, or not. Viruses quickly change and mutate. We haven’t actually discovered all the viruses there are that may be causal factors for various cancers.
3. Immune system problems.
Immunodeficiency, immune susceptibility and chronic inflammation. We all have at any moment in time, cancer cells in us; just like we are also in constant exposure to viruses and bacteria. A healthy immune system will deftly recognize abnormal cells and eliminate them, and will fight off the plethora of bugs that are present in the air, on your skin, on food and objects that you come in contact with. The reason that HIV is so deadly is because this virus targets your immune system and wipes out much of your body’s ability to fight off infections and infections that cause cancers. Most people do not have frank immunodeficiency. People can however have a weakened or nutritionally deficient immune system. Being stressed and deficient in vitamin C might be enough for you to catch a cold from the person that sneezed on the subway. Over time, being deficient in important nutrients like zinc, vitamin C, vitamin D, A, E, selenium etc required by your immune system can be enough to weaken many of your body’s important immunoregulatory processes. Exposure to environmental chemicals challenges your immune system. And lastly, stress impacts all body systems, depletes your immune system and can be the straw that broke the camel’s back that can push a body into the development of chronic disease.The other way that your immune system plays a role in cancer development is via chronic inflammation. If an organ or tissue in your body is chronically inflamed, it also means that there is chronic irritation over and over again to that tissue. If you ran your nail over the same area of skin on your hand over and over again daily, you would develop at wound, then thickened skin, redness and constant soreness. Your skin in that area would eventually respond by producing a scar, a different kind of tissue on your hand. In other areas of your body, such as your intestines, abnormal growths or polyps can develop and eventually DNA damage can occur causing abnormal cell growth and intestinal cancer. People with inflammatory bowel disease have a much higher risk for bowel cancer.Inflammation and cancer: Cancer is inherently an inflammatory process. Chronic inflammation in the body lends itself to the development of the “cancering” process. We now know that fatty tissue is actively inflammatory, thus, obesity increases ones risk of cancer considerably.
4. Genetics:
Only 5% of cancers are genetic.
But children get cancer too. How do these mechanisms makes sense in young people?
Exposure to toxicity and cellular damage starts with the fundamental cells of life: ova and sperm of mom and dad. It then can continue to fetal exposure via the mother’s body-burden of accumulated and stored toxicity. A recent study reported 172 chemicals present in the cord blood of Toronto and Hamilton newborns, most are known carcinogens such as Teflon, flame retardants and pesticides. Studies also show that the average person in Toronto has 400 different fat soluble chemicals stored in their breast tissue, and that a significant amount of the chemical body-burden is relieved after breastfeeding first-born children. Sadly, if breast milk, one of the most important substances in the healthy development of a child were a product, it wouldn’t pass FDA standards.
5. Mitochondrial Damage.
Most of the cancer research to date has been focused on understanding the abnormal genetic factors involved in cancer cell growth. The research of Dr. Thomas Seyfried, PhD, University of Boston, is showing that this may not be the whole story. Dr. Seyfried’s research shows that it’s possible that cancer actually starts with damaged cellular respiration.In each cell of your body, there are specific structures called mitochondria that are responsible for producing energy by burning fuel – fats, carbs, protein-turned-carb with oxygen and other nutrient cofactors. He has shown that cancer doesn’t actually happen without damage to the mitochondria first, and that damage has a role in messing up the genes involved in cellular growth regulatory mechanisms. He showed that transplanting the cell nucleus (the structure containing all genetic material in each cell) of a cancer into a cell with healthy mitochondria doesn’t produce cancer, while transplanting the cell nucleus of a cancer cell into a cell with a damaged mitochondria does. In order for cancer to perpetuate you need the cancer cell to have a malfunctioning mitochondria. Interestingly, the mitochondria in cancer cells can only use carbohydrate and sugar-based fuel to survive on. Cancer cells have many many more receptors for glucose on them than normal cells do, reflecting their increased need for sugar to survive. Sugar and carbohydrate thus feed cancer. This research and clinical findings have promising implications for short term use of ketogenic diets to “starve” cancer.
6. Other
More mechanisms continue to be elucidated with more research.
What is Integrative Cancer Care?
Integrative cancer care is a combination of best approaches to optimize a person’s health, help the body heal, encourage remission, prevent recurrence and support the whole processes. It is not separate from standard conventional therapy, but rather an integration, to optimize health and outcomes, to improve effectiveness and tolerance of chemo, surgery or radiation, to prevent side-effects and harm from treatment and to prevent treatment-induced cancers in the future. The goals are to improve outcomes, quality of life, survival time and prolonged remission. It values treating the individual; the person with cancer vs the cancer.
The focus of the integrative care available here focuses on cancer prevention, integrative care before standard therapies, after standard therapies and recurrence prevention.
Possible Treatment Goals of Integrative Cancer Care:
Surgery prep and optimized recovery.- Rebuilding the body after treatment: clearing brain-fog, chemo-related fatigue, re-building blood counts and immune system resilience.- Prevention of cancer recurrence, prevention of treatment-induced cancers, prolonged cancer-free status.
Defining the Roles of Your Care Team
Surgical oncologist
Specialist to surgical approaches to oncology.
Medical oncologist
Specialist in the chemotherapeutic approach to oncology.
Radiation oncologist
Specialist in the radiation medicine approach to oncology.
Integrative Oncology Care/Naturopathic Doctor with focus and training in oncology
The term Oncologist is reserved for MD’s with specialized education in oncology and chemo-based treatment of cancer. No other practitioner of medicine is allowed to declare specialty in the area of oncology. The term “specialty” is also a prohibited term in medicine reserved for formal education processes. ND’s may focus on particular area of medicine and spend years doing advanced training in a certain area but cannot use the terminology “specializes in” or any form of the word oncologist. The term “treat cancer” also cannot be used. We treat people with cancer.
For that matter, ND’s or MD’s who practice Integrative Oncology Care have a medical focus in whole person supportive care for people with cancer. This specialized knowledge base includes knowledge of chemo drugs, immunotherapy drugs, drugs given in combination with these treatments and radiation side effects. This knowledge-base focuses on evidence-based treatments to support the body in repairing cellular dysregulation, to help cancer cells regain their ability to apoptose (undergo programmed cell death), to down regulate cancer cell growth factors, to sensitize cancer cells to chemo drugs and radiation, to protect healthy cells from damage, preventing side effects of treatment. Treatments involve nutrition, orthomolecular medicine, functional medicine, iv nutrient therapies, injection therapies, stress management and treatments that cleanse, strengthen and re-regulate the body to support healing and resilience.
For that matter, ND’s or MD’s who practice Integrative Oncology Care have a medical focus in whole person supportive care for people with cancer. This specialized knowledge base includes knowledge of chemo drugs, immunotherapy drugs, drugs given in combination with these treatments and radiation side effects. This knowledge-base focuses on evidence-based treatments to support the body in repairing cellular dysregulation, to help cancer cells regain their ability to apoptose (undergo programmed cell death), to down regulate cancer cell growth factors, to sensitize cancer cells to chemo drugs and radiation, to protect healthy cells from damage, preventing side effects of treatment. Treatments involve nutrition, orthomolecular medicine, functional medicine, iv nutrient therapies, injection therapies, stress management and treatments that cleanse, strengthen and re-regulate the body to support healing and resilience.
Integrated Approaches
Integrative care must be individualized to the person, the type of cancer, type of conventional treatment a person is undergoing and the resources and support that a patient has at their disposal and stage of illness.Treatments used are those that are shown to provide successful outcomes in research and clinical practice world-wide. Many are commonly practiced is hospitals, university research clinics, and private practice in Germany, France, Britain, Austria, Italy, India, Russia, Hong Kong, Malaysia, USA and more.
Treatment May Include
Dietary therapy to optimize health, to starve out cancer, improve chemo responses, enhance healing, detoxification support, strengthening. (Keto, Paleo, Vegetarian, Anti-inflammatory, Detoxification)
Specific oral vitamin/supplement protocols
Evidence based treatment support specific to type of cancer and conventional treatment to optimize results. eg mushroom extracts, green tea, IP6, curcumin etc.
Detoxification
Using diet, herbs, nutrients, physical care techniques such as saunas, baths etc.
Cellular restoration
Creating a healthy, anti-cancer cellular environment.
IV nutrients
Pre or post surgery or in cases of deficient nutrition, wasting, or low energy.
Radiation Recovery IV Therapy
Post radiation repair with nutrients, vitamin C and glutathione to aid in recovery and prevention of radiation induced cancers. (starting 2 weeks post radiation).
High Dose Intravenous Vitamin C (HDIVC 50-100g)
Pro-oxidative, anticancer effect, synergistic with chemo, improves tolerance to chemo and radiation, improves quality of life, survival time.
Mistletoe Lectin therapy
Over 350 research papers have proven mistletoe as a safe and effective agent useful in improving chemo tolerance, improving quality of life (energy, mood, nausea, cell count maintenance and immunity, decreased pain), lengthening remission and survival times and have anti-tumor impacts. Mistletoe is part of primary care oncology in hospitals in Germany.
Oxidative therapies such as hyperbarics may be suggested post conventional treatment. Research shows synergistic effects combining HDIVC and the Ketogenic diet.
www.ontarioHBOT.ca
Hyperthermia
Both research and case studies have proven the effectivness of fever induction/or heating body core temperature or local tumor temperature as a treatment to improve the effect of chemo or radiation treatments. Commonly used in European hospitals.
see marsdencentre.com
Cannabis
ND's do not have access to cannabis at this time. Medical grade oils with specific levels of CBD or THC can be helpful for various issues such as pain, nausea, axiety, sleep issues, low appetite. Please see www.cmclinic.ca for access to regulated products dispensed by physicians at appropriate dosages for specific applications. Referrals can be made by your family physician, oncologist or ND.
Glutathione
Used post-radiation.
An Interesting Note on Antioxidants and Cancer
z'Theoretically the use of antioxidants in oncology during chemo and radiation seems counterintuitive. However, the research actually suggests the opposite.http://onlinelibrary.wiley.com/doi/10.1002/ijc.23754/fullIn 19 randomized controlled trials where antioxidants were combined with chemo, the evidence in fact shows no decreased efficacy of chemo, increased survival time, tumor response, fewer toxicities, better chemo tolerance and fewer instances of chemo discontinuation due to dose related toxicities.Anticancer mechanisms of Antioxidants:1. Antioxidants inhibit protein kinase C, restraining tumor cell division and proliferation.2. Antioxidants inhibit oncogene expression (genes that give rise to tumors).3. Antioxidants promote differentiation (promoting normal cell development) by altering growth factors. Undifferentiated cells depart in appearance from highly recognizable differentiated cells of the tissue of origin.4. Antioxidants block the destruction imposed by free radicals, protecting vital tissue from damage.Exceptions: There are 3 antioxidants that have been shown to decrease the effectiveness of radiation or chemo in vivo: NAC, Beta carotene decreased the effectiveness of antimetabolite drugs 5-FU and methotrexate but increased the efficacy of radiotherapy as well as alkylating anthracycline and platinum chemotherapy agents. Tangeretin found in citrus reduced effectiveness of platinum compounds and tamoxifen."
Currently, antioxidants are not used in adjunctive care at VCIM to avoid friction in patient care, patient stress and to maintain good collaborative relationships with all care providers. The available research is nonetheless interesting, and can hopefully be incorporated in care in the future.
Reference Articles
Dr. Keith Block MD: Antioxidants and Cancer Therapy: Furthering the Debatehttp://ict.sagepub.com/content/3/4/342.refs?patientinform-links=yes&legid=spict;3/4/342, http://www.academia.edu/20413304/Antioxidants_and_Cancer_Therapy_Furthering_the_DebateCase Report: The Use of Antioxidants with First Line Chemo Therapy in 2 Patients With Ovarian Cancer: Jeannie Driskco MD https://www.ncbi.nlm.nih.gov/pubmed/12672707Multiple Dietary Antioxidants Enhance The Efficacy of standard and experimental cancer therapies and decrease their toxicity. Kedar N Prasad PhD
Oral antioxidants are avoided during chemo and radiation despite the above research.
High Dose Vitamin C
“The patient should get large doses of vitamin C in all pathological conditions while the physician ponders the diagnosis.” Frederick Robert Klenner, MD.
Indications for Low Dose IVC: (up to 15g)
Scurvy, hemorrhagic disorders, wound healing, allergies, adrenal insufficiency, prevention and anti-aging, fatigue, detoxification of chemicals, prevention of post exercise muscle soreness and improved recovery, immune boosting, colds and flus.
Indications for High Dose IVC (50-100g)
Serious Viral and bacterial infectionsToxins including venomsCancer preventionCancer treatment with and without chemoAcute pancreatitisChronic fatigue
How Does High Does Intravenous Vitamin C Work as an Anticancer Agent?
At lower doses (under 15g), vitamin C acts as an antioxidant, but at high doses it actually becomes a pro-oxidant. Chemo and radiation work because they are very toxic pro-oxidants that damage the DNA in cells. At high doses, given intravenously, vitamin C acts as a pro-oxidant and works synergistically with chemotherapy. Ascorbic acid (vitamin C) is converted to hydrogen peroxide (H2O2) in extracellular fluid. Peroxide enters cancer cells and damages their DNA causing the cells to commit suicide. Your normal, non-cancerous cells contain an enzyme called catalase which neutralizes peroxide into water and oxygen, rendering it harmless. Peroxide radical generation is actually one of your body’s natural mechanisms to dispose of things it doesn’t want – like virus infected cells. Current research and clinical findings have shown that HDIVC helps chemo drugs work better, and helps a person withstand their treatment with far fewer side-effects and much improved quality of life. This is important because if a person has to skip chemo treatments because of poor tolerance, then achieving best tumor kill outcomes with chemo is not possible.Ascorbic Acid (vitamin C) has been validated as supportive therapy in case studies, preclinical trials and cancer cell research. The results of these studies show that AA acts in the following ways:
1) Selective Cytotoxicity (cancer cell killing) Effect
Vitamin C in high doses leads to the production of large amounts of hydrogen peroxide in the connective tissue of the body. Hydrogen peroxide is an important oxidative molecule involved in many immune reactions in the body. In healthy cells the hydrogen peroxide is absorbed and then quenched with intra-cellular anti-oxidants but in cancer cells they often lack sufficient levels of anti-oxidants so hydrogen peroxide will build up. As levels of hydrogen peroxide rise in cancer cells they eventually go through apoptosis (programmed cell death).
2) Inhibition of Tumor Growth and Metastasis
Most tumors require the activity of various enzymes in order to invade and metastasize. Ascorbic Acid inhibits the activity of these enzymes and promotes the production of collagen which may play a role in stabilizing the tumor and preventing local tissue invasion. HDIVC down-regulates angiogenic factors, preventing tumors from developing a blood supply to support their growth. [kim HN. Et.al Vitamin C down-regulates VEGF (vascular endothelial growth factor) production in B16F10 murine melanoma cell via the suppression of p42/44 MAPK activation. J Cell Biochem. 2011 Mar; 112(3):894-901.]Vitamin C also decreases inflammation, an important action in healing, repair and creating an unfriendly environment for cancer cells. Cancer thrives in inflammatory conditions. [via modulation of COX-2 expression]
3) Chemosensitization
Ascorbic Acid has been tested in tissue cultures and animal models in combination with many different chemotherapeutics to evaluate a combined effect on tumors. Most well designed studies have shown a generally positive enhancement of chemotherapeutic success in studies where chemotherapy is combined with AA. There are only a few select studies that show a negative interaction with specific agents. There have been clinical trials evaluating the use of vitamin C in combination with conventional treatments in patients with pancreatic cancer, ovarian cancer and breast cancer. These studies are small, but have shown that high dose vitamin c is well tolerated in cancer patients undergoing certain conventional treatments. It also showed that vitamin C may reduce side effects of conventional treatments, improve patient quality of life and potentially positively impact treatment response.
*At VCIM IVC will not be used during chemo without your physician's or oncologist's approval; most oncologists are not aware of the research, and clinical outcomes, and thus do not support its use. But some do. It is a discussion for you to have with them.
References:
Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., … Levine, M. (2005). Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America, 102(38), 13604–9. doi:10.1073/pnas.0506390102Pathi, S. S., Lei, P., Sreevalsan, S., Chadalapaka, G., Jutooru, I., & Safe, S. (2011). Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutrition and Cancer, 63(7), 1133–42. doi:10.1080/01635581.2011.605984Chen, Q., Espey, M. G., Sun, A. Y., Lee, J.-H., Krishna, M. C., Shacter, E., … Levine, M. (2007). Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proceedings of the National Academy of Sciences of the United States of America, 104(21), 8749–54. doi:10.1073/pnas.0702854104Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., … Levine, M. (2008). Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proceedings of the National Academy of Sciences of the United States of America, 105(32), 11105–9. doi:10.1073/pnas.0804226105Hoffer, L. J., Levine, M., Assouline, S., Melnychuk, D., Padayatty, S. J., Rosadiuk, K., … Miller, W. H. (2008). Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO, 19(11), 1969–74. doi:10.1093/annonc/mdn377Monti, D. a, Mitchell, E., Bazzan, A. J., Littman, S., Zabrecky, G., Yeo, C. J., … Levine, M. (2012). Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PloS One, 7(1), e29794. doi:10.1371/journal.pone.0029794Welsh, J. L., Wagner, B. a, Van’t Erve, T. J., Zehr, P. S., Berg, D. J., Halfdanarson, T. R., … Cullen, J. J. (2013). Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial. Cancer Chemotherapy and Pharmacology, 71(3), 765–75. doi:10.1007/s00280-013-2070-8Vollbracht, C., Schneider, B., Leendert, V., Weiss, G., Auerbach, L., & Beuth, J. (2011). Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany. In Vivo (Athens, Greece), 25(6), 983–990. Retrieved fromMa, Y., Chapman, J., Levine, M., Polireddy, K., Drisko, J., & Chen, Q. (2014). High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Science Translational Medicine, 6(222), 222ra18. doi:10.1126/scitranslmed.3007154www.marsdencentre.com/ivvitaminc
How is High Dose IVC treatment administered? What is the Process?
1. You need to go through an initial intake and assessment with Dr. Grime, ND.2. Your most recent blood work and imaging studies are needed. Most important is serum chemistry and kidney function tests.3. We need to test your G6PD enzyme level to ensure your body can process high dose vitamin C. Approximately 10% of the population is deficient in this enzyme. If you have a deficiency, then your max dose of IVC is 15-20g. G6PD testing can be done by your medical doctor or Dr. Grime, ND. This test is sometimes covered by OHIP and sometimes not. Tammy will give you a requisition for Life Labs, the cost is apprx $60. OHIP does not cover ND requested tests.4. We need to achieve a serum concentration of ascorbic acid 400ng/dl for maximal benefit. Vitamin C is metabolized fairly quickly; so the longer we can achieve this concentration, the more tumor cell killing ability we have. Thus IVC is given 2-3x per week for a minimum of 3 months. Treatments last 1.5 hours. Frequency may be decreased to 1x per week depending on recovery situation.In cases newly achieved remission, to prevent reoccurrence, recommendations are 2 x per week for 3-6 months, then 1 x per week for at least 1 year. IVC will also help your body recover from the carcinogenic effects of chemo and radiation on your healthy cells. 5. Bring a water bottle with you to stay hydrated before, during and after your IV. Make sure you’ve had some food before your IV, bring an apple to maintain your blood sugar. For the benefit of all people’s states and tastes, the IV room has no TV or stereo system. You are welcome to bring personal devices with ear phones, books and magazines.
Adverse Reactions
Thousands of IV’s have been given around the world, hundreds in this office. IVC is very safe, your body has the ability to safely metabolize IVC. Once it is determined that IV’s in general are safe for your system (ie you have good kidney and cardiovascular function), and your G6PD is normal, you will be given increasing doses of IV vitamin C over a few weeks.For most people IV administration is a smooth, eventless process. Somethings that can happen however:Vein ache: can happen in small veins as you get used to IVC. Adding heat resolves the issue.Pain and swelling at the insertion sight: can happen if you bend your arm to much or if the needle is dislodged from the vein (if you move too much). We take the needle out, insert it somewhere else, apply ice. This issue resolves.Bruising: This happens if any blood from your vein leaks into surrounding tissues. This happens more commonly if you don’t hold the cotton over the site for long enough for a clot to form once the needle has been taken out. This kind of bruising is not painful and will resolve in a day or 2.
Mistletoe therapy
European mistletoe is the most widely studied and used complimentary therapy for cancer in Europe. It has a long history of safe and effective use in solid tumours like breast, prostate and colorectal cancer along with systemic cancers like leukemia and multiple myeloma. Many clinical trials and review articles have been conducted which validate the effectiveness of mistletoe in cancer treatment. Recent, good quality, clinical trials have shown viscum to reduce side effects of conventional treatment like chemotherapy, improve quality of life of cancer patients, and potentially positively impact overall survival and recurrence rates in various cancers.It has become the most commonly used natural cancer therapy in Europe and has been validated by hundreds of clinical trials. European mistletoe is a safe non-toxic therapy.European Mistletoe has been widely studied both for its mechanism of action and its clinical effects on cancer patients. Current research has shown the following therapeutic mechanisms of action for mistletoe:
Direct cytotoxic (cancer cell killing) effect
Several components (most notably mistletoe lectins) have strong effect on cancer cells. These components have been shown to cause apoptosis (programmed cell death) in cancer cells.
Inhibition of tumour growth and metastasis
Several animal and human studies have shown an improvement in overall survival and reduced disease progression in individuals receiving mistletoe treatment.
Strong Immunostimulant
Almost all studied components of mistletoe have strong immune stimulating effects well beyond that of other botanicals.
Selective Cytoprotection
Components of mistletoe have been shown to protect the DNA of healthy immune cells. It is believed that this is why patients taking mistletoe alongside standard chemotherapy have fewer side effects and a generally better quality of life.
Strong Neuro-Endocrine Support
Patients receiving treatment with European mistletoe were shown to have improved quality of life in several studies. This translated to improved energy, sleep, appetite and reduced pain.
Review Articles on European Mistletoe
Kienle, G. S., & Kiene, H. (2010). Review article: Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies. Integrative Cancer Therapies, 9(2), 142–57. doi:10.1177/1534735410369673Friedel, W. E., Matthes, H., Bock, P. R., & Zänker, K. S. (2009). Systematic Evaluation of the Clinical Effects of Supportive Mistletoe Treatment within Chemo- and / or Radiotherapy Protocols and Long-Term Mistletoe Application in Nonmetastatic Colorectal Carcinoma : Multicenter , Controlled , Observational Cohort Study, 7(4), 137–145. doi:10.2310/7200.2009.0014Ostermann, T., Raak, C., & Büssing, A. (2009). Survival of cancer patients treated with mistletoe extract (Iscador): a systematic literature review. BMC Cancer, 9, 451. doi:10.1186/1471-2407-9-451Kienle, G. S., Glockmann, A., Schink, M., & Kiene, H. (2009). Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. Journal of experimental & clinical cancer research : CR (Vol. 28). doi:10.1186/1756-9966-28-79
Safety of European Mistletoe
Steele, M. L., Axtner, J., Happe, A., Kröz, M., Matthes, H., & Schad, F. (2014). Safety of Intravenous Application of Mistletoe (Viscum album L.) Preparations in Oncology: An Observational Study. Evidence-Based Complementary and Alternative Medicine : eCAM, 2014, 236310. doi:10.1155/2014/236310Kienle, G. S., Grugel, R., & Kiene, H. (2011). Safety of higher dosages of Viscum album L . in animals and humans – systematic review of immune changes and safety parameters. BMC Complementary and Alternative Medicine, 11(1), 72. doi:10.1186/1472-6882-11-72
Pancreatic Cancer
Tröger, W., Galun, D., Reif, M., Schumann, a, Stanković, N., & Milićević, M. (2013). Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: A randomised clinical trial on overall survival. European Journal of Cancer (Oxford, England : 1990). doi:10.1016/j.ejca.2013.06.043
Colorectal Cancer
Oniu, T., Cazacu, M., Muntean, V., Oniu, M., Mihailov, A., Lungoci, C., & Cluj-napoca, S. C. C. F. (2011). IMUNOTERAPIA CU EXTRACT DE VISCUM ALBUM ÎN TRATAMENTUL CANCERULUI COLORECTAL AVANSAT, 7(4).
Lung Cancer
Bar-Sela, G., Wollner, M., Hammer, L., Agbarya, A., Dudnik, E., & Haim, N. (2013). Mistletoe as complementary treatment in patients with advanced non-small-cell lung cancer treated with carboplatin-based combinations: A randomised phase II study. European Journal of Cancer (Oxford, England : 1990), 49(5), 1058–64. doi:10.1016/j.ejca.2012.11.007
Liver Cancer
Mabed, M., El-Helw, L., & Shamaa, S. (2004). Phase II study of viscum fraxini-2 in patients with advanced hepatocellular carcinoma. British Journal of Cancer, 90(1), 65–9. doi:10.1038/sj.bjc.6601463
Mixed Cancers
Piao, B. K., Wang, Y. X., Xie, G. R., Mansmann, U., Matthes, H., Beuth, J., & Lin, H. S. (2004). Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Research, 24(1), 303–9. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1501561*the above organization of references was taken from http://www.marsdencentre.com/european-mistletoe
What is low dose naltrexone?
3.0 to 4.5 mg at bedtime causes Endorphin/enkephalin blockade.In morning there is a flood of endorphins and enkephalins etc.Cancer cells have enkephalin receptors that slow cellular growth.Several papers (Plotnikoff NP, Zagon I etc.) have shown that increased met-enkephalin (opiate growth factor, OGF) production slows the growth of cancer cells by attaching to their receptors.Low-dose naltrexone may reverse the development of tolerance of opioids by it’s binding to filamin A (cell cytoskeleton).-Endogenous opioids are known to produce analgesia. An increase in endogenous opioids through LDN use may result in less pain.-LDN binds to Toll-Like Receptor 4 (TLR4 activates innate immune cells), thus blocking inflammatory Lipo-Poly-Saccharides (LPS). This action prevents the LPS from producing inflammation. http://www.ldnresearchtrust.org/sites/default/files/Bert%20Berkson%202013%20LDN%20CONFERENCE.pdf
LDN is not accessible by an ND, however, your MD or Oncologist may support it's use.
The Ketogenic Diet and Cancer
Research on calorie restriction and cancer prevention: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829867/Articles and Research on Ketogenic Diet to augment Cancer treatment http://articles.mercola.com/sites/articles/archive/2013/06/16/ketogenic-diet-benefits.aspxThe Ketogenic Diet for the Treatment of Malignant Glioma http://www.jlr.org/content/early/2014/02/06/jlr.R046797.full.pdfResearch on Ketogenic Diet + Hyperbaric Oxygen+IVC http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522Interview with Dr. Jeannie Drisko, MD on her research and case studies and success using combined chemo therapy, ketogenic diet, IVC and hyperbaric oxygen. http://www.prescription2000.com/current-research/rx2000-interviews/754-2013-12-06-jeannie-drisko-cancer-iv-vitamin-c-ketogenic-diet-hbot
Dr. Grime’s Training in IV Medicine
Make sure that you are choosing a properly trained and experienced practitioner.In order to be able to perform IV therapy, in Ontario, you need to be1. An ND, MD or nurse2. Have advanced training in IV therapy beyond naturopathic medical school3. Have passed written and practical examinations, board certified.4. Maintain a specific IV Therapy license.Dr. Grime, ND has been in practice since 2006 and has been providing IV nutrient therapy since 2009. In addition, she has significant training in phlebotomy/venipuncture as she worked as a technician at MDS labs between university and medical school. She is able to access portacaths and picc lines.
Getting Started
Not sure if Dr. Grime can help? Want to meet her first and learn some basic information about integrated cancer care? <
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br>Book a 30 minute introductory appointment to learn some general basics about naturopathic approaches to cancer, what treatment will look like and get a chance to meet the doctor. Visit fee for consultation is $80.
Option A)
Not sure if Dr. Grime can help? Want to meet her first and learn some basic information about integrated cancer care? <
/
br><
/
br>Book a 30 minute introductory appointment to learn some general basics about naturopathic approaches to cancer, what treatment will look like and get a chance to meet the doctor. Visit fee for consultation is $80.
Option B)
Get started right away. You need to do an initial intake with the doctor so that she understands you, your cancer type and stage, what kind of cancer you have, what your conventional treatment has been or is currently, what other ailments you have and the general state of your health. She will then put together an care plan for you and will begin implementing it on subsequent visits. It can take 3-4 visits initially to get a plan fully implemented. We need to gather all the information needed and to implement a care plan covers nutrition, detoxing, supplementation and injection therapies; depending on patient goals. Initial intakes are 60 minutes. Bring copies of your most recent labs and imaging studies. There is much to learn about how you will be getting your body stronger. After the initial few appointments, you will be monitored 1x every 4-6 weeks, and aspects of your treatment changed as you progress though the steps of care, possible conventional treatment and repair.Surround yourself with positive-can-do people, movies, books, cases, groups.
Cancer Resources
Well Spring Organization, cancer support centre: https://wellspring.ca/Gilda’s Club Cancer Support Community: https://gildasclubtoronto.org/Center for Mindfulness Studies, Cancer specific program: http://www.mindfulnessstudies.com/personal/other/cancer/Ellicsr: Health, Wellness and Cancer Survivorship Centre at Toronto General Hospital: https://www.ellicsr.ca/en/
Interesting Research on Various Cancer Types
Books
Cancer as a Metabolic Disease by Thomas Seyfreid, PhD (ketogenic diet)Anti-Cancer by Dr. David Servan-Schreiber, MD, PhDIntegrative Cancer Care: the power of being informed by Dr. Adam Mcleod, ND
Brain Cancer
Research on Ketogenic Diet and Brain Cancer http://www.jlr.org/content/early/2014/02/06/jlr.R046797.full.pdfhttp://www.academia.edu/8115481/Could_Metabolic_Therapy_Become_a_Viable_Alternative_to_the_Standard_of_Care_for_Managing_GlioblastomaCannabis oil studies: http://www.ncbi.nlm.nih.gov/pubmed/17934890
Breast Cancer
(up load Dr. Jen Green’s powerpoint)Additional Therapy with a Mistletoe Product during Adjuvant Chemotherapy of Breast Cancer Patients Improves Quality of Life: An Open Randomized Clinical Pilot Trial.Tröger W1, Zdrale Z2, Tišma N2, Matijašević M2. http://www.ncbi.nlm.nih.gov/pubmed/24701238Articles and Research on IVC in Cancer Therapy and it’s Pro-oxidative action at high dose. (The reason why it’s not contraindicated with to use with chemo)
Published research
http://www.kumc.edu/school-of-medicine/pharmacology-toxicology-and-therapeutics/faculty/qi-chen-phd-.html
High Dose IV Vitamin C (IVC)
http://www.cancer.gov/cancertopics/pdq/cam/highdosevitaminc/patient/page2http://www.medicalnewstoday.com/articles/117494.php
Research Papers on IVC
High dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapyAuthors: Yan Ma1,2, Julia Chapman3, Mark Levine4, Kishore Polireddy1,2, Jeanne Drisko2*,Qi Chen1,2“Administering high dose intravenous ascorbate in combination with chemotherapy in newly diagnosed advanced stage 3 or stage 4 ovarian cancer.” High dose IV C given with paclitaxel and carboplatin: Five times less adverse events in the IVC arm than the control arm.Conclusion: Intravenous ascorbate, recognized as a prooxidative therapy with wide clinical use and remarkable safetly record, together with suggested trend to benefit when combined with traditional cancer care, warrants larger prospective study in regards to its role in cancer treatment. Sullivan, G. et al. (2011, November).Synergistic Effects of Ascorbate with Carboplatin against Human Ovarian Cancer in Vitro and in Vivo”.Conclusion: our data demonstrated that a combination of high dose parenteral ascorbate and carboplatin exhibited synergistic activity against human ovarian cancer both in vitro and in vovo, via enhanced DNA damage in cancer cells. Ma, Y. Drisko, J.Poilreeddy, K. (2011, November)“Pharmacologic ascorbate synergizes with gemcitabine in pre-clinical models of pancreatic cancer.” In vitro and invo models of pancreatic cancer. “A strong synergistic effect was eveident between high dose parenteral ascorbate and gemcitabine both in vitro and in vivo. Ma, Y. et. Al. (20011 November). Pharmacologic ascorbate synergizes with gemcitabine in pre-clinical models of pancreatic cancer. Moderated abstract [19] presented at the society for Integrative Oncology, Cleaveland, OH.“Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs.” AScorbate as an antiproliferative apoptotic agent – MOA is cell cycle arrest. AScorbate pre-treatment as a chemosensitizer for Docetaxal, Epirubicin, Irinotecan and 5-FU. Fromber, A, et al. Cemother pharmacol, 67:1157-1166, 2011.Phase 1 Evaluation of Intravenous Ascorbic Acid In combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. Mark Levine et alPharmacologicascorbatesynergizes with gemcitabine in preclinical models of pancreatic cancerPharmacologic doses of ascobate act asa prooxidant and decrease growth of aggressive tumor xenografts in miceIntravenous administered vitamin C as cancer therapy: 3 cases http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405876/http://www.ncbi.nlm.nih.gov/pubmed/22963460 Effect of intravenous vitamin C on inflammation in cancerhttp://www.ncbi.nlm.nih.gov/pubmed/22021693 Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany.Cameron E, Campbell A: The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer. Chem Biol Interact 9 (4): 285-315, 1974. [PUBMED Abstract]Cameron E, Campbell A, Jack T: The orthomolecular treatment of cancer. III. Reticulum cell sarcoma: double complete regression induced by high-dose ascorbic acid therapy. Chem Biol Interact 11 (5): 387-93, 1975. [PUBMED Abstract]Cameron E, Pauling L: Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A 73 (10): 3685-9, 1976. [PUBMED Abstract]Moertel CG, Fleming TR, Creagan ET, et al.: High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med 312 (3): 137-41, 1985. [PUBMED Abstract]Padayatty SJ, Riordan HD, Hewitt SM, et al.: Intravenously administered vitamin C as cancer therapy: three cases. CMAJ 174 (7): 937-42, 2006. [PUBMED Abstract]http://www.webmd.com/cancer/news/20140205/intravenous-vitamin-c-may-boost-chemos-cancer-fighting-power
Articles on High-Dose Intravenous Vitamin C Therapy for Cancer
http://www.ncbi.nlm.nih.gov/pubmed/23947403http://www.ncbi.nlm.nih.gov/pubmed/22963460http://www.ncbi.nlm.nih.gov/pubmed/24022818http://www.ncbi.nlm.nih.gov/pubmed/15313465http://www.ncbi.nlm.nih.gov/pubmed/11960609
Breast Cancer
http://www.ncbi.nlm.nih.gov/pubmed/22021693
Brain Cancer
http://www.pnas.org/content/105/32/11105